Malignant phaeochromocytoma and hypercalcaemia.

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Malignant phaeochromocytoma and hypercalcaemia.

We describe a case of hypercalcaemia secondary to recurrent malignant phaeochromocytoma. Parathyroid-related protein (PTHrp 1-86) immunoreactivity was identified in plasma and PTHrp was identified by immunocytochemistry in tumour tissue.

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Phaeochromocytoma and hypercalcaemia.

Introduction Phaeochromocytoma may occasionally induce hypercalcaemia. Case reports of correction of hypercalcaemia by surgical removal of the phaeochromocytoma indicate the importance of humoral mechanisms (Swinton, Clerkin and Flint, 1972; Kukreja et al., 1973). Kukreja et al. (1973) noted a pre-operative elevation of serum immuno-reactive parathyroid hormone (i-PTH) implying that hypercalcae...

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Hypercalcaemia and phaeochromocytoma.

A patient with a phaeochromocytoma associated with hypercalcemia is described. The hypercalcaemia was corrected by removal of the phaeochromocytoma. Parathyroid hormone-like peptide was isolated from the tumour suggesting that ectopic parathyroid hormone production from the phaeochromocytoma was the explanation of the hypercalcaemia.

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Hypercalcaemia in malignant lymphoma.

Three patients with malignant lymphoma complicated by hypercalaemia without radiological bone abnormality are described. The medical literature has been reviewed and the possible underlying mechansims discussed. The early diagnosis of this potentially fatal complication is important since this may respond (together with the underlying disease) to appropriate chemotherapy.

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Mithramycin treatment of malignant hypercalcaemia.

Medical Memoranda MnWLJOUL 167 I would like to thank Dr. A. Brown for permission to publish this report and for helpful advice and criticism. My thanks are also due to Dr. George McDonald, who carried out the iliac crest biopsy. Mithramycin is an antibiotic with anti-tumour activity similar to actinomycin D. Hypocalcaemia has been reported following its use (Brown and Kennedy, 1965), and it has...

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ژورنال

عنوان ژورنال: Postgraduate Medical Journal

سال: 1993

ISSN: 0032-5473

DOI: 10.1136/pgmj.69.807.77